BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
Synonyms:
BMPR-II, BMPR3, BMR2, BRK-3, PPH1, T-ALK
Species:
Human BMPR2 (659), Mouse Bmpr2 (12168), Rat Bmpr2 (140590), cow BMPR2 (407127), naked mole-rat Bmpr2 (101701138), Domestic Rabbit BMPR2 (100350246), sheep BMPR2 (101103793), domestic guinea pig Bmpr2 (100736232), chicken BMPR2 (374147), sheep BMPR2 (100294556) ...More
UniProtKB ID:
Gene ID:
- Human(659) Summary: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
- Mouse(12168) bone morphogenetic protein receptor, type II (serine/threonine kinase)
- Rat(140590) bone morphogenetic protein receptor, type II (serine/threonine kinase)
- cow(407127) bone morphogenetic protein receptor, type II (serine/threonine kinase)
- naked mole-rat(101701138) bone morphogenetic protein receptor, type II (serine/threonine kinase)
- Domestic Rabbit(100350246) bone morphogenetic protein receptor, type II (serine/threonine kinase)
- sheep(101103793) bone morphogenetic protein receptor, type II (serine/threonine kinase)
- domestic guinea pig(100736232) bone morphogenetic protein receptor, type II (serine/threonine kinase)
- chicken(374147) bone morphogenetic protein receptor, type II (serine/threonine kinase)
- sheep(100294556) bone morphogenetic protein receptor, type II (serine/threonine kinase)
- domestic cat(101096338) bone morphogenetic protein receptor, type II (serine/threonine kinase)
- dog(478875) bone morphogenetic protein receptor, type II (serine/threonine kinase)
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-BMPR2 antibody produced in mouse, clone 3F6, ascites fluid,
Species Reactivity
human, monkey, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-BMPR2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-BMPR2 Mouse mAb (4A2), liquid, clone 4A2, Calbiochem®,
Species Reactivity
human
Application