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Merck

BACE2

beta-site APP-cleaving enzyme 2

Synonyms:
AEPLC, ALP56, ASP1, ASP21, BAE2, CEAP1, DRAP
Species:
Human BACE2 (25825), Mouse Bace2 (56175), Rat Bace2 (288227), domestic cat BACE2 (101096756), cow BACE2 (534774), domestic guinea pig Bace2 (100720853), dog BACE2 (478418), naked mole-rat Bace2 (101717943), chicken BACE2 (418526), sheep BACE2 (101102027)
UniProtKB ID:
Q9Y5Z0, A8K7P1, Q5DIH8, Q8N2D4, Q9H2V8, Q9NZL1, Q9NZL2, Q9UJT6
Gene ID:
  • Human(25825) Summary: This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  • Mouse(56175) beta-site APP-cleaving enzyme 2
  • Rat(288227) beta-site APP-cleaving enzyme 2
  • domestic cat(101096756) beta-site APP-cleaving enzyme 2
  • cow(534774) beta-site APP-cleaving enzyme 2
  • domestic guinea pig(100720853) beta-site APP-cleaving enzyme 2
  • dog(478418) beta-site APP-cleaving enzyme 2
  • naked mole-rat(101717943) beta-site APP-cleaving enzyme 2
  • chicken(418526) beta-site APP-cleaving enzyme 2
  • sheep(101102027) beta-site APP-cleaving enzyme 2

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