ASIC2
acid-sensing (proton-gated) ion channel 2
Synonyms:
ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1
Species:
Human ASIC2 (40), Mouse Asic2 (11418), Rat Asic2 (25364), sheep ASIC2 (101120341), Zebrafish asic2 (407669), domestic cat ASIC2 (101096183), domestic guinea pig Asic2 (100717745)
UniProtKB ID:
Gene ID:
- Human(40) Summary: This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
- Mouse(11418) acid-sensing (proton-gated) ion channel 2
- Rat(25364) acid-sensing (proton-gated) ion channel 2
- sheep(101120341) acid-sensing (proton-gated) ion channel 2
- Zebrafish(407669) acid-sensing (proton-gated) ion channel 2
- domestic cat(101096183) acid-sensing (proton-gated) ion channel 2
- domestic guinea pig(100717745) acid-sensing (proton-gated) ion channel 2
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