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Merck

ACVR1

activin A receptor, type I

Synonyms:
ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
Species:
Human ACVR1 (90), Mouse Acvr1 (11477), Rat Acvr1 (79558), domestic guinea pig Acvr1 (100724428), naked mole-rat Acvr1 (101711343), chicken ACVR1 (395246), dog ACVR1 (478757), domestic cat ACVR1 (101091298), Horse ACVR1 (100050899), cow ACVR1 (338068)
UniProtKB ID:
Q04771
Gene ID:
  • Human(90) Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
  • Mouse(11477) activin A receptor, type 1
  • Rat(79558) activin A receptor, type I
  • domestic guinea pig(100724428) activin A receptor, type I
  • naked mole-rat(101711343) activin A receptor, type I
  • chicken(395246) activin A receptor, type I
  • dog(478757) activin A receptor, type I
  • domestic cat(101091298) activin A receptor, type I
  • Horse(100050899) activin A receptor, type I
  • cow(338068) activin A receptor, type I
  • sheep(443161) activin A receptor, type I

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1306388
ANTI-ACTIVIN RECEPTOR TYPE IA (ACVR1) (CENTER R147) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
SAB3500435
Anti-ACVR1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
western blot
SAB2500024
Anti-ACVR1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
SAB2108587
Anti-ACVR1, affinity isolated antibody,
Species Reactivity
bovine, goat, guinea pig, horse, human, mouse
Application
immunohistochemistry
western blot
SAB1402682
Monoclonal Anti-ACVR1 antibody produced in mouse, clone 2D5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot