- Enantioselective syntheses of (R)- and (S)-argentilactone and their cytotoxic activities against cancer cell lines.
Enantioselective syntheses of (R)- and (S)-argentilactone and their cytotoxic activities against cancer cell lines.
Bioorganic & medicinal chemistry (2004-09-25)
Angelo de Fatima, Luciana Konecny Kohn, Márcia Aparecida Antônio, João Ernesto de Carvalho, Ronaldo Aloise Pilli
PMID15388170
ABSTRACT
Concise total syntheses of (R)- and (S)-argentilactone have been developed via enantioselective catalytic allylation (ECA) and ring-closing metathesis pathways (four steps, 39% overall yield and 82-84% ee) from 2-octynal and their in vitro activity against cancer cells is described.
MATERIALS