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Regulation and function of pyruvate kinase M2 in cancer.

Cancer letters (2013-06-25)
Weiwei Yang, Zhimin Lu
ABSTRACT

Altered metabolism is fundamental to the growth and survival of cancer cells. Pyruvate kinase M2 (PKM2), a key enzyme in cancer metabolism, has been demonstrated to play a central role not only in metabolic reprogramming but also in direct regulation of gene expression and subsequent cell cycle progression. This review outlines the current understanding of PKM2 protein kinase activity and regulatory mechanisms underlying PKM2 expression, enzymatic activity, and nuclear localization, thus highlighting PKM2 as a potential therapeutic target.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Pyruvate Kinase from rabbit muscle, Type II, ammonium sulfate suspension, 350-600 units/mg protein
Sigma-Aldrich
Pyruvate Kinase from rabbit muscle, Type VII, buffered aqueous glycerol solution, 350-600 units/mg protein
Sigma-Aldrich
Pyruvate Kinase from rabbit muscle, Type III, lyophilized powder, 350-600 units/mg protein
Sigma-Aldrich
Pyruvate Kinase from Bacillus stearothermophilus, Type VIII, lyophilized powder, 100-300 units/mg protein
Sigma-Aldrich
Pyruvate kinase M2 Active from mouse, recombinant, expressed in E. coli, ≥90% (SDS-PAGE)