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  • Synthesis and cytotoxic effect of carbocyclic potential minor groove binders.

Synthesis and cytotoxic effect of carbocyclic potential minor groove binders.

Farmaco (Societa chimica italiana : 1989) (2004-02-28)
Danuta Bartulewicz, Tomasz Anchim, Milena Dabrowska, Krystyna Midura-Nowaczek
ABSTRACT

New carbocyclic potential minor groove binders were synthesised, using 3-nitrobenzoyl chloride and aliphatic alpha,omega-diamines with three, four and five methylene fragments. The half structures, compounds IV-VI can be compared to bis-amidines, compounds X-XII to bis-netropsin. All of the compounds were investigated antiproliferative and cytotoxic effects in the standard cell line of mammalian tumour MCF-7.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3-Nitrobenzoyl chloride, 98%