2,6-Dimethylphenol: a new metabolite of mexiletine.

2,6-Dimethylphenol: a new metabolite of mexiletine.

Research communications in chemical pathology and pharmacology (1987-10-01)

O Grech-Bélanger, J Turgeon, M Lalande

ABSTRACT

A new metabolite, 2,6-dimethylphenol obtained by O-dealkylation of mexiletine by rabbit liver was identified. A g.c.-f.i.d. method was developed for its analysis in hepatic homogenates and some of the characteristics of the metabolic reaction were studied. Formation of 2,6-dimethylphenol is microsomal and is optimal under aerobic conditions. Both carbon monoxide and n-octylamine significantly depress this O-dealkylation reaction.

MATERIALS

Product Number

Brand

Product Description

W324906

Sigma-Aldrich

2,6-Xylenol, ≥99%, FG

D174904

Sigma-Aldrich

2,6-Dimethylphenol, ≥99.5%

D175005

Sigma-Aldrich

2,6-Dimethylphenol, 99%

36715

Supelco

2,6-Dimethylphenol, PESTANAL^®, analytical standard