- Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres.
Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres.
Angewandte Chemie (International ed. in English) (2012-11-07)
Amirali Popat, Benjamin P Ross, Jian Liu, Siddharth Jambhrunkar, Freddy Kleitz, Shi Zhang Qiao
PMID23129230
ABSTRACT
I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released.