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  • Delta-cyclodextrin as novel chiral probe for enantiomeric separation by electromigration methods.

Delta-cyclodextrin as novel chiral probe for enantiomeric separation by electromigration methods.

Electrophoresis (2006-10-06)
Dorothee Wistuba, Anja Bogdanski, Kim L Larsen, Volker Schurig
ABSTRACT

Native delta-CD has been employed as chiral selector in CE and MEKC. To investigate the potential of the enantiodiscriminating properties of delta-CD, negatively charged 5-dimethylamino-1-naphthalene-sulfonyl (dansyl)-, 2,4-dinitrophenyl (DNP)- and FMOC-derivatives of several amino acids, 1,1'-binaphthyl-2,2'-diylhydrogenphosphate, flavanones and three positively charged drugs have been selected as testing samples. Enantioresolution factors up to 4.82 have been observed. The results were compared with those achieved by the conventional running buffer additives alpha-, beta- and gamma-CDs. For several examples a steady increase of enantioresolution with increasing degree of oligomerization has been detected.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(S)-(+)-1,1′-Binaphthyl-2,2′-diyl hydrogenphosphate, 97%
Sigma-Aldrich
(R)-(−)-1,1′-Binaphthyl-2,2′-diyl hydrogenphosphate, ≥98%
Sigma-Aldrich
1,1′-Binaphthyl-2,2′-diyl hydrogenphosphate, 95%