- Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus).
Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus).
Journal of natural products (2005-02-01)
Feng Zhao, Yuki Watanabe, Hajime Nozawa, Akihiro Daikonnya, Keiji Kondo, Susumu Kitanaka
PMID15679315
ABSTRACT
The ethyl acetate soluble fraction of hops (Humulus lupulus) showed potent inhibitory activity on the production of nitric oxide (NO) induced by a combination of LPS and IFN-gamma. Four known prenylflavonoids (1-4) and a new prenylflavonoid (5), hulupinic acid (6), lupulone (7), and its six new derivatives (8-13) were isolated from the active fraction. The structures were determined on the basis of physiochemical properties and spectroscopic analysis. Their inhibitory activities on the production of NO in macrophage RAW 264.7 cells were examined.
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