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  • Highly diastereo- and enantioselective NHC-catalyzed [3+2] annulation of enals and isatins.

Highly diastereo- and enantioselective NHC-catalyzed [3+2] annulation of enals and isatins.

Chemical communications (Cambridge, England) (2011-08-11)
Li-Hui Sun, Li-Tao Shen, Song Ye
ABSTRACT

The chiral N-heterocyclic carbene bearing a proximal hydroxy group derived from L-pyroglutamic acid was found to be an efficient catalyst for the [3+2] annulation of enals and isatins to give the corresponding spirocyclic oxindolo-γ-butyrolactones in good yield with good diastereo- and enantioselectivities.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
L-Pyroglutamic acid, BioXtra