Avanti® Polar Lipids
Lipidomics research, a sub-field of metabolomics, studies the structure and function of the entire set of lipids in a cell or biological system, also called the lipidome, and their interactions with other cellular components to discover biomarkers of pathological disorders.
As the exclusive partner of Avanti® Polar Lipids for all countries except the United States, we strive to make high-purity lipids more accessible to researchers around the world. We provide a comprehensive portfolio of Avanti® lipids, adjuvants, and equipment used in drug delivery solutions for complex therapeutic drugs and next generation mRNA vaccines. All Avanti® products meet stringent quality and stability control standards.
- More than 2,000 Avanti® products with >99% purity
- High-purity natural and synthetic phospholipids, sphingolipids, and sterol lipids
- Fluorescent lipids, adjuvants, lipid-binding antibodies, and more
- Lipidomics tools for studying lipid structure and function
- Avanti® Mini-Extruder for liposome preparation
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Adjuvants in Immunotherapy & Vaccine Development
Related Product Resources
- Catalog: Pure Expertise - Avanti® Polar Lipids
- Brochure: Lipidomics - Connecting Lipids, Technology and Cellular Biology
- Data Sheet: LIPIDOMIX® Quantitative Mass Spec Standards
- Data Sheet: EquiSPLASH™ LIPIDOMIX® Quantitative Mass Spec Internal Standard Avanti® Product Number 330731-1EA
- Lipidomics Magazine Volume 3
Free booklet with leading lipid research from European Journal of Lipid Science and Technology from Wiley
- Data Sheet: Quantitative 31P-NMR Analysis of Phospholipid Mixtures
- Data Sheet: Quantitative Lipidomics Analysis – Comprehensive Coverage with Accurate Quantitation
- Avanti® Mini-Extruder Extrusion Technique
Watch the below video for instructions on liposome preparation using the Avanti® Mini-Extruder.
- Free Metabolomics Brochure
Whether your metabolomics research involves targeted or untargeted metabolomics workflows, our integrated approach for profiling, pinpointing and designating compounds provides efficient and reliable results. This reference guide provides a brief overview of these products.
Adjuvants in Immunotherapy & Vaccine Development
Vaccine adjuvants using heterogeneous monophosphoryl Lipid A (MPL) derived from Salmonella minnesota R595 have proven to be safe and effective at inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines. The Avanti® team revolutionized immunotherapy and vaccine development with the introduction of synthetic MPL derivatives and adjuvant systems. We offer multiple Avanti® synthetic analogs of MPL containing a single molecular species that have been shown to be effective and safe at inducing an immune response as their natural product predecessor. PHAD®, 3D-PHAD®, and 3D(6A)-PHAD® have been tested extensively in animals using a variety of antigens. In all cases, these adjuvants exhibit a similar activity and safety profile to bacterially-derived MPL.
UltimateSPLASH™ ONE
UltimateSPLASH™ ONE is the complete internal standard solution for quantitative lipidomics. It consists of one vial containing 69 high-purity deuterium-labeled internal standards covering 15 lipid classes. Each vial contains 1.2 ml of 1:1 DCM:MeOH solution that has been meticulously characterized, quantitated, and blended for accurate quantitation using multiple lipidomics techniques.
LIPID MAPS® Mass Spec Standards
Avanti® is the exclusive licensed manufacturer and supplier of LIPID MAPS® Mass Spec Standards for lipid analysis, including glycerolipids, glycerophopholipids, sphingolipids, and sterols. Quantitative standards are used to identify the structure or concentration of molecular species in mass spectrometry. Qualitative standards are used to tag DNA polymerase for the general identification of lipids by mass spectrometry analysis. Whatever your application, Avanti® chemically pure synthetic lipid standards are characterized and prepackaged in unit containers at defined concentrations. A detailed certificate of analysis accompanies each standard.
Equipment
The Avanti® Mini Extruder allows you to prepare large, unilamellar vesicles by extrusion in an efficient manner. Generate uniform populations of unilamellar liposomes without the use of solvents or detergents. Vesicle size is controlled by polycarbonate membrane selection. The particle size distribution of unilamellar vesicles prepared by extrusion is a function of the number of passes through the extruder membrane. Placing the stabilizer block-extruder assembly on a hot plate achieves rapid temperature control for lipids that have transition temperatures above room temperature. The special design, constructed of stainless steel and Teflon, allows for rapid cleaning of all wetted parts, reducing “down-time” between production of vesicles from different lipid species.
Dr. Anne Bendt - LipidMaps Podcast
This episode of the LipidMaps podcast features Dr. Anne Bendt, Deputy Director of the world-renowned Singapore Lipidomics Incubator (SLING). SLING specializes in mass spectrometry-based lipid analysis and, under Dr. Bendt's leadership, prioritizes practical applications and partnerships in academia and industry.
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