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SML2945

Sigma-Aldrich

SGC-STK17B-1

≥98% (HPLC)

Synonym(s):

2-((6-(Benzo[b]thiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl)thio)acetic acid, 2-(6-(Benzo[b]thiophen-2-yl)thieno[3,2-d]pyrimidin-4-ylthio)acetic acid

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About This Item

Empirical Formula (Hill Notation):
C16H10N2O2S3
CAS Number:
2650530-00-8
Molecular Weight:
358.46
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(O)CSC1=C2C(C=C(C3=CC4=CC=CC=C4S3)S2)=NC=N1

Biochem/physiol Actions

SGC-STK17B-1 is a cell penetrant, potent and selective inhibitor of STK17B/DRAK2 kinase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alfredo Picado et al.
Journal of medicinal chemistry, 63(23), 14626-14646 (2020-11-21)
STK17B is a member of the death-associated protein kinase family and has been genetically linked to the development of diverse diseases. However, the role of STK17B in normal and disease pathology is poorly defined. Here, we present the discovery of

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