SML1412

KRIBB11 trifluoroacetate salt

≥98% (HPLC)

• Synonym(s): 2,6-Pyridinediamine trifluoroacetate salt, N2-(1H-Indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine trifluoroacetate salt, N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine trifluoroacetate salt
• Empirical Formula (Hill Notation): C₁₃H₁₂N₆O₂ · C₂HF₃O₂
• CAS Number: 342639-96-7
• Molecular Weight: 398.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825859
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CNC1=NC(NC2=CC=C(NN=C3)C3=C2)=C([N+]([O-])=O)C=C1.FC(F)(C(O)=O)F
• InChI: 1S/C13H12N6O2.C2HF3O2/c1-14-12-5-4-11(19(20)21)13(17-12)16-9-2-3-10-8(6-9)7-15-18-10;3-2(4,5)1(6)7/h2-7H,1H3,(H,15,18)(H2,14,16,17);(H,6,7)
• InChI key: DNBQMABUWGNHGB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

KRIBB11 is an inhibitor of the transcription factor Heat Shock Factor 1 (HSF1) with an IC₅₀ value of 1.2 μM. KRIBB11 blocks induction of HSF1 downstream target proteins such as HSP27 and HSP70 by impairing the recruitment of Positive Transcription Elongation Factor b (P-TEFb) to the HSF1 transcriptional complex, preventing HSF1-mediated gene expression KRIBB11 inhibits tumor growth in vivo and acts synergistically to increase apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin and 17-AAG.

KRIBB11 is capable of preventing the proliferation of cancer cells. It has the ability to stimulate apoptosis and can arrest the cell cycle at G2/M phase.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable