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SML0151

Sigma-Aldrich

CCT036477

≥98% (HPLC)

Synonym(s):

α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine

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About This Item

Empirical Formula (Hill Notation):
C21H18ClN3
CAS Number:
305372-78-5
Molecular Weight:
347.84
MDL number:
MFCD01831143
UNSPSC Code:
12352200
PubChem Substance ID:
329825199
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥20 mg/mL (warm to 60°C)

storage temp.

−20°C

SMILES string

Cc1[nH]c2ccccc2c1C(Nc3ccccn3)c4ccc(Cl)cc4

InChI

1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)

InChI key

IFOHRIXRQPOHQZ-UHFFFAOYSA-N

Biochem/physiol Actions

CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Linwei Li et al.
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Journal of hematology & oncology, 8, 63-63 (2015-06-07)
Mantle cell lymphoma (MCL) is an aggressive and incurable form of non-Hodgkin's lymphoma. Despite initial intense chemotherapy, up to 50% of cases of MCL relapse often in a chemoresistant form. We hypothesized that the recently identified MCL-initiating cells (MCL-ICs) are

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