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H8759

Sigma-Aldrich

4-Hydroxy-3-methoxyphenylglycol sulfate potassium salt

≥98% (HPLC), powder

Synonym(s):

(3-Methoxy-4-sulfonyloxyphenyl)glycol potassium salt, MHPG sulfate potassium salt, MOPEG sulfate potassium salt

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About This Item

Empirical Formula (Hill Notation):
C9H11KO7S
CAS Number:
71324-20-4
Molecular Weight:
302.34
Beilstein:
4625651
MDL number:
MFCD00043417
UNSPSC Code:
12352200
PubChem Substance ID:
24277755
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

off-white

solubility

H2O: 50 mg/mL

storage temp.

2-8°C

SMILES string

[K+].COc1cc(ccc1OS([O-])(=O)=O)C(O)CO

InChI

1S/C9H12O7S.K/c1-15-9-4-6(7(11)5-10)2-3-8(9)16-17(12,13)14;/h2-4,7,10-11H,5H2,1H3,(H,12,13,14);/q;+1/p-1

InChI key

XFZJWBFZLNLKNR-UHFFFAOYSA-M

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Biochem/physiol Actions

Norepinephrine metabolite that is often used as an index of adrenergic stimulation.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K W Perry et al.
Journal of neural transmission (Vienna, Austria : 1996), 104(8-9), 953-966 (1997-01-01)
The selective serotonin uptake inhibitor fluoxetine (10 mg/kg i.p.) increased tissue levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethylene glycol sulfate (MHPG-SO4) in rat hypothalamus, indicating an increased release of norepinephrine. Microdialysis studies in conscious rats showed that fluoxetine (10 mg/kg i.p.)
E T Hellriegel et al.
Pharmacology, biochemistry, and behavior, 57(1-2), 207-214 (1997-05-01)
The objective of this investigation was to examine the immediate and long term effects of acute, chronic and chronic intermittent stress on the central noradrenergic system of rats. Male Sprague-Dawley rats were subjected to one hour of physical immobilization stress
G Eisenhofer et al.
Journal of neurochemistry, 66(4), 1565-1573 (1996-04-01)
This study used regional differences in plasma concentrations of norepinephrine and its metabolites to examine how production of the transmitter by sympathetic nerves, in particular, those innervating mesenteric organs, is integrated with metabolism by the liver and elimination by the
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

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