60765

Silica gel

high-purity grade, with ~15% calcium sulfate and fluorescent indicator, GF₂₅₄, suitable for thin layer chromatography (TLC)

• CAS Number: 112926-00-8
• EC Number: 231-545-4
• MDL number: MFCD00011232
• UNSPSC Code: 41115711
• PubChem Substance ID: 329759214
• NACRES: NC.07

Properties

• grade: high-purity grade
• Quality Level: 100
• form: powder
• quality: with ~15% calcium sulfate and fluorescent indicator
• manufacturer/tradename: Sigma-Aldrich
• technique(s): thin layer chromatography (TLC): suitable
• surface area: 500 m²/g
• particle size: <20 μm; >632 mesh
• pore size: 0.8 cm³/g pore volume; 60 Å pore size
• bp: 2230 °C
• mp: >1600 °C
• SMILES string: O=[Si]=O
• InChI: 1S/O2Si/c1-3-2
• InChI key: VYPSYNLAJGMNEJ-UHFFFAOYSA-N

Description

General description

Silica gel is a rigid 3D network of colloidal silica. It is exclusively used as a support material for the active titanium(III) centers in Ziegler-Natta catalysts. Silica gel allows a controlled fragmentation resulting in the formation of uniform polymer particles with narrow particle size distribution and high bulk density. Silica gel is classified as below:
a. Aquagel - pores are filled with water
b. Xerogel - by the process of evaporation, aqueous phase in the pores are removed
c. Aerogel - solvent is removed by supercritical extraction

Application

• Chromatographic Separation: Silica gel is widely used as a stationary phase in chromatography for the separation of various chemical compounds. Innovations in silica gel modification, such as pentabromobenzyl group-modified silica gel, have enhanced the separation efficiency for metabolites like nicotinamide. This application is critical for pharmaceutical analysis and metabolomics studies, providing high precision and accuracy in the quantification of biologically relevant molecules (Ozaki et al., Analytical Biochemistry, 2022).


• Environmental Pollutant Detection: Silica gel is used to create molecularly imprinted polymers (MIPs) that selectively recognize and bind environmental pollutants. A notable application involves the embedding of quantum dots in molecularly imprinted silica gel to detect aminoimidazo-azaarenes (AIAs) in food samples. This method offers high selectivity and sensitivity, making it a powerful tool for food safety and environmental monitoring (Qiao et al., Current Analytical Chemistry, 2021).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves