73328

Trimethylsilyl cyanide

technical, ≥95% (GC)

• Synonym(s): Cyanotrimethylsilane, TMSCN
• Linear Formula: (CH₃)₃SiCN
• CAS Number: 7677-24-9
• Molecular Weight: 99.21
• Beilstein: 1737612
• EC Number: 231-657-3
• MDL number: MFCD00001765
• UNSPSC Code: 12352100
• PubChem Substance ID: 57652474
• NACRES: NA.22

Properties

• grade: technical
• Assay: ≥95% (GC)
• form: liquid
• refractive index: n20/D 1.392 (lit.)
• bp: 114-117 °C (lit.)
• mp: 8-11 °C (lit.)
• density: 0.793 g/mL at 20 °C (lit.)
• SMILES string: C[Si](C)(C)C#N
• InChI: 1S/C4H9NSi/c1-6(2,3)4-5/h1-3H3
• InChI key: LEIMLDGFXIOXMT-UHFFFAOYSA-N

Description

Application

Trimethylsilyl cyanide (TMSCN) can be used as a reagent in the:

• Cyanosilylation of carbonyl compounds using various catalysts.
• Synthesis of α-aminonitriles by one-pot, three-component Strecker reaction of ketones with various amines using Brønsted acid catalyst.
• Cyanation of aryl halides using palladium-complex as a catalyst.

Safety Information

• Pictograms: GHS02,GHS06,GHS09
• Signal Word: Danger
• Hazard Statements: H225,H300 + H310 + H330,H410
• Precautionary Statements: P210 - P264 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Flam. Liq. 2
• Supplementary Hazards: EUH014,EUH029
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 33.8 °F - closed cup
• Flash Point(C): 1 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves