Key Documents

View All Documentation

Amastatin hydrochloride hydrate

Name: Amastatin hydrochloride hydrate
Brand: SIGMA

powder, ≥97% (HPLC)

Synonym(s):

(2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp hydrochloride hydrate

Select a Size

Change View

Size/SKU	Availability	Price

About This Item

Empirical Formula (Hill Notation):

C₂₁H₃₈N₄O₈ · HCl · xH₂O

CAS Number:

100938-10-1

Molecular Weight:

511.01 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24890521

UNSPSC Code:

12352202

MDL number:

MFCD00150636

Beilstein/REAXYS Number:

8888370

Pricing and availability is not currently available.

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Amastatin hydrochloride hydrate, ≥97% (HPLC)

biological source

synthetic (organic)

Quality Segment

200

assay

≥97% (HPLC)

form

powder

mp

202-205 °C

solubility

methanol: 1 mM (Stock solution stable for 1 month at −20 °C. Working solution stable for 1 day.)

antibiotic activity spectrum

neoplastics

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

Cl[H].[H]O[H].CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C21H38N4O8.ClH.H2O/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27;;/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33);1H;1H2/t12-,13+,15+,16+,17+;;/m1../s1

InChI key

WBYDQJQQTMJMQH-AFROIDPFSA-N

Description

General description

Chemical structure: peptide

Biochem/physiol Actions

Amastatin is a slow, tight-binding inhibitor of aminopeptidases. It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts Angiotensin II to Angiotensin III. Effective concentration: 1-10 μM.

It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.

Effective concentration: 1-10 μM.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	A6191	SML0056	B8385
Sigma-Aldrich A1276 Amastatin hydrochloride hydrate	Sigma-Aldrich A6191 Antipain dihydrochloride from microbial source	Sigma-Aldrich SML0056 Cefotiam dihydrochloride hydrate	Sigma-Aldrich B8385 Bestatin hydrochloride
assay ≥97% (HPLC)	assay -	assay ≥98% (HPLC)	assay ≥98% (HPLC)
biological source synthetic (organic)	biological source Streptomyces sp.	biological source -	biological source synthetic (organic)
Quality Level 200	Quality Level 300	Quality Level 100	Quality Level 300
form powder	form lyophilized powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
solubility methanol: 1 mM (Stock solution stable for 1 month at −20 °C. Working solution stable for 1 day.)	solubility H₂O: 50 mg/mL, 1-butanol: soluble, 1-propanol: soluble, DMSO: soluble, ethanol: soluble, methanol: soluble	solubility H₂O: ≥22 M	solubility water: 25 mg/mL, clear to very slightly hazy, colorless

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.