761591

(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride

95%

• Synonym(s): Benzylamino tetrazine hydrochloride, H-Tz-Bz-NH₃Cl hydrochloride
• Empirical Formula (Hill Notation): C₉H₉N₅ · xHCl
• CAS Number: 1345866-68-3
• Molecular Weight: 187.20 (free base basis)
• MDL number: MFCD23097050
• UNSPSC Code: 12352116
• PubChem Substance ID: 329766561
• NACRES: NA.22

Properties

• Assay: 95%
• form: solid
• reaction suitability: reaction type: click chemistry; reagent type: linker
• mp: 206-225 °C (decomposition)
• functional group: amine
• storage temp.: −20°C
• SMILES string: NCC1=CC=C(C2=NN=CN=N2)C=C1.[H]Cl
• InChI: 1S/C9H9N5.ClH/c10-5-7-1-3-8(4-2-7)9-13-11-6-12-14-9;/h1-4,6H,5,10H2;1H
• InChI key: FAAUXGMWUKVOPI-UHFFFAOYSA-N

Description

General description

4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine is a 1,2,4,5-tetrazine derivative capable of undergoing [4+2] Diels-Alder cycloaddition reactions with strained alkenes, which makes it highly useful in bioorthogonal labeling and cell detection applications.

Application

Amine functionalized tetrazine for inverse electron demand Diels-Alder cycloaddition reactions. The tetrazine will react with strained alkenes such as transcyclooctene, norbornene and cyclopropene to yield a stable covalent linkage. Tetrazines have proven useful in bioorthogonal reactions for many biological imaging and bioconjugation applications.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301,H315,H319,H335
• Precautionary Statements: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable