- Copper-catalyzed intermolecular carboetherification of unactivated alkenes by alkyl nitriles and alcohols.
Copper-catalyzed intermolecular carboetherification of unactivated alkenes by alkyl nitriles and alcohols.
Angewandte Chemie (International ed. in English) (2015-03-05)
Claire Chatalova-Sazepin, Qian Wang, Glenn M Sammis, Jieping Zhu
PMID25736186
RESUMEN
A three-component carboetherification of unactivated alkenes has been developed allowing the rapid building of complexity from simple starting materials. A wide range of α-substituted styrenes underwent smooth reactions with unactivated alkyl nitriles and alcohols to afford γ-alkoxy alkyl nitriles with concomitant generation of a quaternary carbon center. A radical clock experiment provided clear-cut evidence that the reaction proceeds through a tertiary alkyl radical intermediate.
MATERIALES
Referencia del producto
Marca
Descripción del producto
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad