Saltar al contenido
Merck

Synthesis and glycosidase inhibitory activity of 1-amino-3,6-anhydro-1-deoxy-D-sorbitol derivatives.

Bioorganic chemistry (2010-01-12)
Stéphane Guillarme, Jean-Bernard Behr, Claudia Bello, Pierre Vogel, Christine Saluzzo
RESUMEN

3,6-Anhydro-1-(aryl or alkylamino)-1-deoxy-D-sorbitol derivatives have been prepared in four steps from isosorbide, a by-product from the starch industry. The inhibitory activities of these new compounds have been evaluated towards 13 glycosidases. A first lead-compound was identified, which inhibited beta-N-acetylglucosaminidase from bovine kidney (82% inhibition at 1mM).

MATERIALES
Referencia del producto
Marca
Descripción del producto

USP
Isosorbide, United States Pharmacopeia (USP) Reference Standard
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad