- An assessment of the clastogenic potential of 4-chloromethylbiphenyl in human lymphocytes in vitro.
An assessment of the clastogenic potential of 4-chloromethylbiphenyl in human lymphocytes in vitro.
Mutation research (1982-01-01)
C R Richardson, J Wildgoose
PMID7057762
RESUMEN
The clastogenic potential of 4CMB was assessed in vitro in human lymphocytes from 4 donors (2 male and 2 female) both with and without auxiliary metabolic activation. Although there were some variation in the response of the cells from different donors to 4CMB using 2 criteria for interpretation of the results; it was concluded that 4CMB was a clastogen, but only at dose levels that caused some cytotoxicity. The response was amplified by the inclusion of chromatid and chromosome gaps in the analysis of chromosome damage.
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