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Merck

Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.

Antimicrobial agents and chemotherapy (2015-09-02)
Ranae M Ranade, Zhongsheng Zhang, J Robert Gillespie, Sayaka Shibata, Christophe L M J Verlinde, Wim G J Hol, Erkang Fan, Frederick S Buckner
RESUMEN

The methionyl-tRNA synthetase (MetRS) is a novel drug target for the protozoan pathogen Giardia intestinalis. This protist contains a single MetRS that is distinct from the human cytoplasmic MetRS. A panel of MetRS inhibitors was tested against recombinant Giardia MetRS, Giardia trophozoites, and mammalian cell lines. The best compounds inhibited trophozoite growth at 500 nM (metronidazole did so at ∼5,000 nM) and had low cytotoxicity against mammalian cells, indicating excellent potential for further development as anti-Giardia drugs.

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Diamond Vitamin Tween® 80 Solution 40x, frozen liquid, suitable for cell culture
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Número de referencia del producto (SKU)Referencia (SKU) del distribuidorTamaño de envaseDisponibilidadPrecio
SS-5272-500MG500 mg
Se envía en 21 días desde el socio de Aldrich
AUD 1.129,41
SS-5272-1G1 g
Se envía en 21 días desde el socio de Aldrich
AUD 1.731,00

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