Saltar al contenido
Merck

860062P

Avanti

Brain SM

Avanti Research - A Croda Brand

Sinónimos:

18:0 SM; Octadecanoyl Sphingomyelin; N-octadecanoyl-D-erythro-sphingosylphosphorylcholine; N-(octadecanoyl)-sphing-4-enine-1-phosphocholine

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Número de CAS:
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25

En este momento no podemos mostrarle ni los precios ni la disponibilidad

description

Sphingomyelin (Brain, Porcine)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (860062P-1g)
pkg of 1 × 200 mg (860062P-200mg)
pkg of 1 × 25 mg (860062P-25mg)
pkg of 1 × 500 mg (860062P-500mg)

manufacturer/tradename

Avanti Research - A Croda Brand

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O

InChI

1S/C41H83N2O6P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-41(45)42-39(38-49-50(46,47)48-37-36-43(3,4)5)40(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h32,34,39-40,44H,6-31,33,35-38H2,1-5H3,(H-,42,45,46,47)/b34-32+/t39-,40+/m0/s1

Comparar elementos similares

Ver comparación completa

Mostrar Diferencias

1 of 4

Este artículo
860061P860062C860063P
Brain SM Avanti Research™ - A Croda Brand

860062P

Brain SM

Egg SM Avanti Research™ - A Croda Brand

860061P

Egg SM

Brain SM Avanti Research™ - A Croda Brand

860062C

Brain SM

Milk SM Avanti Research™ - A Croda Brand

860063P

Milk SM

manufacturer/tradename

Avanti Research - A Croda Brand

manufacturer/tradename

Avanti Research - A Croda Brand

manufacturer/tradename

Avanti Research - A Croda Brand

manufacturer/tradename

Avanti Research - A Croda Brand

packaging

pkg of 1 × 1 g (860062P-1g), pkg of 1 × 25 mg (860062P-25mg), pkg of 1 × 200 mg (860062P-200mg), pkg of 1 × 500 mg (860062P-500mg)

packaging

pkg of 1 × 1 g (860061P-1g), pkg of 1 × 200 mg (860061P-200mg), pkg of 1 × 25 mg (860061P-25mg)

packaging

pkg of 1 × 2.5 mL (860062C-25mg), pkg of 2 × 4 mL (860062C-200mg)

packaging

pkg of 1 × 200 mg (860063P-200mg), pkg of 1 × 25 mg (860063P-25mg)

form

powder

form

powder

form

liquid

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

As a major constituent of cell membranes, sphingomyelin is found at particularly high concentrations in the membranes of nerve cells (in the myelin sheaths) and red blood cells. It was previously thought to have a purely structural role, similar to the function of phosphatidylcholine, through intermolecular interactions mediated by the 2-amide group, the 3-hydroxy group and the 4,5-trans double bond of the sphingoid base.[1] However, it is now appreciated that sphingomyelin has a high affinity for cholesterol and that these two lipids pack tightly into liquid-ordered domains among a liquid-disordered phase to form lipid rafts.[1] These membrane microdomains are thought to function as signaling platforms that regulate the localization and interactions of proteins. But sphingomyelin does not just influence signaling as a component of lipid rafts — it is also a precursor to ceramides and other sphingolipid metabolites that comprise the sphingomyelin cycle or sphingolipid network.[1]
Sphingomyelin and related lipids

Application

Brain SM is suitable:
  • as a standard for high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS)[2]
  • as a supplement for cell vacuolation of Hela cells[3]
  • for preparation of liposomes[4]

Packaging

20 mL Clear Glass Screw Cap Vial (860062P-500mg)
5 mL Amber Glass Screw Cap Vial (860062P-200mg)
5 mL Amber Glass Screw Cap Vial (860062P-25mg)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (860062P-1g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids


  • Elija entre una de las versiones más recientes:

    Certificados de análisis (COA)

    Lot/Batch Number

    Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

    Si necesita más asistencia, póngase en contacto con Atención al cliente

    ¿Ya tiene este producto?

    Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

    Visite la Librería de documentos

    Lipid raft components cholesterol and sphingomyelin increase H+/OH- permeability of phosphatidylcholine membranes
    Gensure R H, et al.
    The Biochemical Journal, 398(3), 485-495 (2006)
    Sphingomyelin functions as a novel receptor for Helicobacter pylori VacA
    Gupta VR, et al.
    PLoS Pathogens, 4(5), e1000073-e1000073 (2008)
    Distinct disruptions in Land's cycle remodeling of glycerophosphocholines in murine cortex mark symptomatic onset and progression in two Alzheimer's disease mouse models
    Granger M W, et al.
    Journal of Neurochemistry (2018)
    Yusuke Sato et al.
    Acta biomaterialia, 102, 341-350 (2019-11-17)
    Despite the fact that small-sized lipid nanoparticles (LNPs) are important for improved tissue penetration and efficient drug delivery, their poor stability and intracellular trafficking significantly hinders their use as potent small-sized LNPs. It has been reported that both the diffusion
    Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids.
    Milhas D, et al.
    Febs Letters, 584, 1887-1894 (2010)

    Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

    Póngase en contacto con el Servicio técnico