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  • Diazinium salts with dihydroxyacetophenone skeleton: Syntheses and antimicrobial activity.

Diazinium salts with dihydroxyacetophenone skeleton: Syntheses and antimicrobial activity.

European journal of medicinal chemistry (2008-08-02)
Ana Maria Balan, Ondina Florea, Costel Moldoveanu, Gheorghita Zbancioc, Dorina Iurea, Ionel I Mangalagiu
ABSTRACT

Herein we report a feasible study concerning syntheses, structure and antimicrobial activity of some new diazinium salts with dihydroxyacetophenone skeleton. A fast, general, environmentally friendly, and facile method for preparation of diazinium salts under microwave and ultrasounds irradiation is presented. Antimicrobial tests prove that some diazine compounds have a remarkable activity against different microorganisms (germs and fungi), the pyrimidine derivatives being more active. Correlations between structure and antimicrobial activity are reported.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2′,6′-Dihydroxyacetophenone, 97%
Supelco
2′,6′-Dihydroxyacetophenone, matrix substance for MALDI-MS, ≥99.5%