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  • Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells.

Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells.

Journal of synchrotron radiation (2013-02-16)
Erin J Sheridan, Christopher J D Austin, Jade B Aitken, Stefan Vogt, Katrina A Jolliffe, Hugh H Harris, Louis M Rendina
ABSTRACT

The first example of synchrotron X-ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first quantitative analysis of the incorporation of a bromine-labelled cyclic RGD peptide and its effects on the biodistribution of endogenous elements (for example, K and Cl) within individual tumor cells.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Arg-Gly-Asp, ≥97% (TLC)
Sigma-Aldrich
Bromine water, CP
Sigma-Aldrich
Bromine, JIS special grade, ≥99.0%
Sigma-Aldrich
Bromine, SAJ first grade, ≥97.0%
Sigma-Aldrich
Bromine, ≥99.99% trace metals basis
Sigma-Aldrich
Bromine, reagent grade
Sigma-Aldrich
Bromine, ACS reagent, ≥99.5%