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Ag(I)-catalyzed aminofluorination of alkynes: efficient synthesis of 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.

Ag(I)-catalyzed aminofluorination of alkynes: efficient synthesis of 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.

Organic letters (2012-10-24)

Tao Xu, Guosheng Liu

ABSTRACT

A silver-catalyzed intramolecular oxidative aminofluorination of alkynes has been developed by using NFSI as a fluorinating reagent. This reaction represents an efficient method for the synthesis of various 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Silver nitrate, tested according to Ph. Eur.

Sigma-Aldrich

Silver nitrate, 99.9999% trace metals basis

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Silver nitrate, meets analytical specification of Ph. Eur., BP, USP, 99.8-100.5%

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Silver nitrate, puriss. p.a., ≥99.5% (AT)

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Sigma-Aldrich

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