3779

Histamine, Free Base

• Synonym(s): Histamine, Free Base
• Empirical Formula (Hill Notation): C₅H₉N₃
• CAS Number: 51-45-6
• Molecular Weight: 111.15
• MDL number: MFCD00005210
• UNSPSC Code: 12352209
• NACRES: NA.77

Properties

• Assay: ≥97% (TLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
• InChI key: NTYJJOPFIAHURM-UHFFFAOYSA-N

Description

General description

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase.

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase. Formed by the decarboxylation of L-histidine. Activation of histamine H₁ receptors leads to Ca²⁺ mobilization, whereas histamine H₂ receptor activation stimulates adenylate cyclase activity in neurons. Stimulated time- and concentration-dependent increase in p38 and p42/p44 MAP kinases in DDT(1) MF2 cells.

A potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H₁ receptors leads to Ca²⁺ mobilization; whereas, histamine H₂ receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H₂ receptor activation.

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol.133, 178.
Izumi, H., et al. 1995. Am. J. Obstet. Gynecol.172, 1477.
Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem.269, 9952.
Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301,H315,H317,H319,H334,H335
• Precautionary Statements: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable