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  • Discovery of human-like L-asparaginases with potential clinical use by directed evolution.

Discovery of human-like L-asparaginases with potential clinical use by directed evolution.

Scientific reports (2017-09-02)
Coraline Rigouin, Hien Anh Nguyen, Amanda M Schalk, Arnon Lavie
PMID28860480
ABSTRACT

L-asparaginase is a chemotherapy drug used to treat acute lymphoblastic leukemia (ALL). The main prerequisite for clinical efficacy of L-asparaginases is micromolar K

MATERIALS
Product Number
Brand
Product Description
M2634
Sigma-Aldrich
Malic Dehydrogenase from porcine heart, buffered aqueous glycerol solution, 600-1000 units/mg protein (biuret)
G2751
Sigma-Aldrich
Glutamic-Oxalacetic Transaminase from porcine heart, Type I, ammonium sulfate suspension, 200-500 units/mg protein