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  • Pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects.

Pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects.

Chirality (2012-08-14)
Man Liu, Dan Zhang, Man Yang, Ting Zhao, Xiaolin Wang, Yanan Zhang, Jing Han, Huichen Liu
ABSTRACT

The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2-mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h in 12 healthy subjects. The plasma concentrations of (+)-(R)-terazosin at all time points were higher than those of (-)-(S)-terazosin. The area under the plasma concentration-time curve (AUC(0-∞) ) and maximum plasma concentration of (+)-(R)-terazosin were significantly greater than those of the (-)-(S)-terazosin (P < 0.01, respectively). The R/S ratio of AUC(0-∞) of terazosin was 1.68. For the first time, it was proven that the pharmacokinetics of terazosin was stereoselective in healthy Chinese male subjects.

MATERIALS
Product Number
Brand
Product Description

Terazosin hydrochloride dihydrate, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Terazosin hydrochloride, ≥98% (TLC), powder