- Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines.
Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines.
Frontiers in microbiology (2018-02-15)
Mónica G Malmierca, Lorena González-Montes, Ignacio Pérez-Victoria, Carlos Sialer, Alfredo F Braña, Raúl García Salcedo, Jesús Martín, Fernando Reyes, Carmen Méndez, Carlos Olano, José A Salas
PMID29441046
RESUMEN
Many bioactive natural products are glycosylated compounds in which the sugar components usually participate in interaction and molecular recognition of the cellular target. Therefore, the presence of sugar moieties is important, in some cases essential, for bioactivity. Searching for novel glycosylated bioactive compounds is an important aim in the field of the research for natural products from actinomycetes. A great majority of these sugar moieties belong to the 6-deoxyhexoses and share two common biosynthetic steps catalyzed by a NDP-