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Computational Design and Synthesis of Novel Fluoro-Analogs of Combretastatins A-4 and A-1.

Journal of fluorine chemistry (2018-01-10)
Yao Zong, Christie Shea, Katherine Maffucci, Iwao Ojima
RESUMEN

Combretastatin A-1 (CA-1) and combretastatin A-4 (CA-4) isolated from the African bush willow

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Sigma-Aldrich
4-(Difluoromethoxy)benzaldehyde, 95%
Sigma-Aldrich
3-fluoro-4-(trifluoromethoxy)benzaldehyde, AldrichCPR