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AIE fluorophore with enhanced cellular uptake for tracking esterase-activated release of taurine and ROS scavenging.

Faraday discussions (2016-11-29)
Jun Wang, Yinglong Wu, Fang Zeng, Shuailing Huang, Shuizhu Wu
RESUMEN

Fluorophores with aggregation-induced emission (AIE) characteristics are attractive and versatile tools for both chemical sensing and biological imaging. Herein, we designed and synthesized a fluorescent light-up system CTPE-Tau with enhanced cellular uptake ability. The system possesses several advantages, such as a large Stokes shift, low cytotoxicity, and good photostability. Also, it has been successfully utilized to track esterase-activated release of taurine and to scavenge intracellular ROS, and shows great potential for trackable visualized therapy.

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Sigma-Aldrich
4-Formylphenylboronic acid, ≥95.0%
Sigma-Aldrich
4-Bromobenzophenone, 98%