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Thioredoxin induces Tregs to generate an immunotolerant tumor microenvironment in metastatic melanoma.

Thioredoxin induces Tregs to generate an immunotolerant tumor microenvironment in metastatic melanoma.

Oncoimmunology (2015-09-26)

Xiaogang Wang, Haisheng Dong, Qi Li, Yingxian Li, An Hong

RESUMEN

Metastatic melanoma is a highly aggressive cancer that is very difficult to treat. Additionally, the antitumor immune reaction of melanoma is still unclear. Here we demonstrate an association between the expression and secretion of the antioxidant protein thioredoxin (TRX) and increasing tumor stage and metastasis in melanoma. To elucidate the role of TRX in melanoma, we assessed the correlation of TRX expression with different disease parameters in melanoma. We also examined the

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Peróxido de hidrógeno solution, 30 % (w/w) in H₂O, contains stabilizer

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Alcohol etílico puro, 200 proof, anhydrous, ≥99.5%

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1,4 Dioxano, anhydrous, 99.8%, contains <=25 ppm BHT as stabilizer

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Alcohol etílico puro, 190 proof, ACS spectrophotometric grade, 95.0%

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Alcohol etílico puro, 190 proof, meets USP testing specifications

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Peróxido de hidrógeno solution, 34.5-36.5%

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Peróxido de hidrógeno solution, SAJ first grade, ≥30.0%

Supelco

Ethanol solution, 10 % (v/v) in H₂O, analytical standard

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Etanol, ≥99.5%, suitable for HPLC

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Etanol, JIS special grade, 94.8-95.8%

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Etanol, ≥99.5%

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Ethanol solution, suitable for fixing solution (blood films)

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Etanol, JIS first grade, 94.8-95.8%

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Etanol, ≥99.5%, suitable for absorption spectrum analysis

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9,10-Dihydroacridine, Aldrich^CPR

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Peróxido de hidrógeno solution, contains potassium stannate as inhibitor, 30-32 wt. % in water, semiconductor grade, 99.999% trace metals basis

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Etanol, ≥99.5%, SAJ super special grade

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1,4 Dioxano, JIS special grade, ≥99.0%

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Etanol, ≥99.5%, suitable for fluorescence

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Etanol, JIS 300, ≥99.5%, for residue analysis

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Etanol, JIS 1000, ≥99.5%, for residue analysis

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1,4 Dioxano, suitable for HPLC

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1,4 Dioxano, SAJ first grade