Saltar al contenido
MilliporeSigma

MUM1/IRF4: A Review.

Applied immunohistochemistry & molecular morphology : AIMM (2010-02-26)
Gabriela Gualco, Lawrence M Weiss, Carlos E Bacchi
RESUMEN

MUM1/IRF4 protein is a member of the interferon regulatory factor (IRF) family of transcriptional factors initially described as downstream regulators of interferon signaling. The quantity of this factor varies within the hematopoietic system in a lineage and stage-specific way. It is considered to be a key regulator of several steps in lymphoid, myeloid, and dendritic cell differentiation and maturation. MUM1/IRF4 expression is observed in many lymphoid and myeloid malignancies, and may be a promising target for the treatment of some of these neoplasms. We reviewed the literature on MUM1/IRF4, with emphasis on the pathologic aspects of this marker in reactive and malignant hematologic and nonhematologic conditions.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
MUM1 (EP190) Rabbit Monoclonal Primary Antibody