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  • 2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.

Bioorganic & medicinal chemistry letters (2002-07-13)
Richard L Mackman, Hon C Hui, J Guy Breitenbucher, Bradley A Katz, Christine Luong, Arnold Martelli, Danny McGee, Kesavan Radika, Martin Sendzik, Jeffrey R Spencer, Paul A Sprengeler, James Tario, Erik Verner, Jing Wang
PMID12113832
RESUMEN

The development of potent and selective urokinase-type plasminogen activator (uPA) inhibitors based on the lead molecule 2-(2-hydroxy-3-ethoxyphenyl)-1H-benzimidazole-5-carboxamidine (3a) is described.