- Genomic methods for clinical and translational pain research.
Genomic methods for clinical and translational pain research.
Methods in molecular biology (Clifton, N.J.) (2012-02-22)
Dan Wang, Hyungsuk Kim, Xiao-Min Wang, Raymond Dionne
PMID22351080
RESUMEN
Pain is a complex sensory experience for which the molecular mechanisms are yet to be fully elucidated. Individual differences in pain sensitivity are mediated by a complex network of multiple gene polymorphisms, physiological and psychological processes, and environmental factors. Here, we present the methods for applying unbiased molecular-genetic approaches, genome-wide association study (GWAS), and global gene expression analysis, to help better understand the molecular basis of pain sensitivity in humans and variable responses to analgesic drugs.
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Bromothymol Blue sodium salt, for microscopy (Bot., Hist., Vit.), indicator (pH 6.0-7.6)