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Anxiolytic and antidepressant effects of aqueous tincture of the aerial part of Myosotis arvensis.

Bulletin of experimental biology and medicine (2012-03-31)
N Yu Polomeyeva, R V Gurto, O S Bryushinina, V A Slepichev, A V Kaigorodtsev, V Yu Smirnov, N I Suslov, V V Udut
RESUMEN

Experiments on outbred albino mice showed a significant anxiolytic effect of aqueous tincture of the aerial part of Myosotis arvensis (L.) (Boraginaceae) in a single daily dose of 0.5 ml/kg. In a dose of 2 ml/kg, the tincture of M. arvensis aerial part exhibited an anxiolytic and antidepressant effect. In contrast to phenazepam, aqueous tincture of M. arvensis did not inhibit exploratory and motor activities.

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Phenazepam solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®