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Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.

The Journal of pharmacy and pharmacology (1988-02-01)
E A Formukong, A T Evans, F J Evans
RESUMEN

Tetrahydrocannabinol (THC) induced catalepsy in mice, whereas a cannabis oil (6.68% w/w THC), four cannabinoids and a synthetic mixture did not. Cannabinol (CBN) and olivetol inhibited THC-induced catalepsy in the mornings and the evenings, but cannabidiol (CBD) exhibited this effect only in the evenings. A combination of CBN and CBD inhibited THC-induced catalepsy equal to that of CBN alone in the mornings, but this inhibition was greater than that produced by CBN alone in the evenings.

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Olivetol, 95%