Direct access to enantioenriched spiroacetals through asymmetric relay catalytic three-component reaction.

Direct access to enantioenriched spiroacetals through asymmetric relay catalytic three-component reaction.

Organic letters (2013-01-15)

Hua Wu, Yu-Ping He, Liu-Zhu Gong

PMID23312017

RESUMEN

The gold(I)/chiral Brønsted acid relay catalysis enabled a highly stereoselective three-component reaction of salicylaldehydes, anilines, and alkynols to give aromatic spiroacetals in high yields and stereoselectivities.

MATERIALES

Referencia del producto

Marca

Descripción del producto

S356

Sigma-Aldrich

Salicylaldehyde, reagent grade, 98%

84160

Sigma-Aldrich

Salicylaldehyde, redist., ≥99.0% (GC)

W300403

Sigma-Aldrich

Salicylaldehyde, ≥98%, FG

03273

Supelco

Salicylaldehyde, analytical standard