- High prevalence of fluoroquinolone-resistant group B streptococci among clinical isolates in China and predominance of sequence type 19 with serotype III.
High prevalence of fluoroquinolone-resistant group B streptococci among clinical isolates in China and predominance of sequence type 19 with serotype III.
Antimicrobial agents and chemotherapy (2013-01-09)
Hui Wang, Chunjiang Zhao, Wenqiang He, Feifei Zhang, Liyan Zhang, Bin Cao, Ziyong Sun, Yingchun Xu, Qing Yang, Yaning Mei, Bijie Hu, Yunzhuo Chu, Kang Liao, Yunsong Yu, Zhidong Hu, Yuxing Ni
PMID23295933
RESUMEN
A total of 146 group B streptococcus isolates from 8 cities across China belonged to four serotypes. Serotype Ia was more common in children. A high prevalence of resistance was observed for levofloxacin (37.7%), erythromycin (71.2%), clindamycin, (53.4%), and tetracycline (81.5%). The levofloxacin and clindamycin resistances among the 4 serotypes differed significantly. Eighty percent of fluoroquinolone-resistant isolates belonged to the sequence type 19 (ST19)/serotype III clone, with GyrA-ParC-ParE triple substitutions. This clone carried the erm(B), mef(E), and tet(M) genes.
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Clindamycin hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Clindamicina hydrochloride, European Pharmacopoeia (EP) Reference Standard