Saltar al contenido
MilliporeSigma
  • Asymmetric synthesis of 4,5,6- and 3,4,5,6-substituted azepanes by a highly diastereoselective and enantioselective lithiation-conjugate addition sequence.

Asymmetric synthesis of 4,5,6- and 3,4,5,6-substituted azepanes by a highly diastereoselective and enantioselective lithiation-conjugate addition sequence.

Journal of the American Chemical Society (2006-02-16)
Suk Joong Lee, Peter Beak
RESUMEN

Asymmetric syntheses of 4,5,6- and 3,4,5,6-substituted azepanes have been achieved by highly diastereoselective and enantioselective (-)-sparteine-mediated asymmetric lithiation-conjugate additions of N-Boc-N-(p-methoxyphenyl)-2,3-substituted allylamines to a beta-aryl alpha,beta-unsaturated ester followed by hydrolysis, cyclization, and reduction. Access to the enantiomeric adduct is provided by an invertive lithiation-stannylation-lithiation sequence.

MATERIALES
Referencia del producto
Marca
Descripción del producto

Sigma-Aldrich
N-Benzylmethylamine, 97%
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Número de referencia del producto (SKU)Tamaño de envaseDisponibilidadPrecioCantidad
25 mL
En stock
Detalles...
$41.60
100 mL
En stock
Detalles...
$49.10
500 mL
En stock
Detalles...
$88.40