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Recoverable fluorous CBS methodology for asymmetric reduction of ketones.

Organic letters (2005-07-16)
Zoltán Dalicsek, Ferenc Pollreisz, Agnes Gömöry, Tibor Soós
RESUMEN

[reaction: see text]. An operationally simple and recoverable fluorous CBS methodology was developed. The in situ-generated fluorous oxazaborolidine efficiently catalyzed the reduction of ketones with high enantioselectivity and reactivity. The subsequent recycling of the fluorous prolinol precatalyst was achieved by fluorous solid-phase extraction.

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Sigma-Aldrich
Trimethylboroxine, 99%
Sigma-Aldrich
(S)-(+)-2-Pyrrolidinemethanol, 97%