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A novel one-pot, four component synthesis of some densely functionalized pyrroles.

Molecular diversity (2004-04-08)
Javad Azizian, Ali R Karimi, Hamedeh Arefrad, Ali A Mohammadi, M R Mohammadizadeh
RESUMEN

A new one-pot four component procedure for synthesis of densely functionalized pyrroles using commercially available ninhydrin with phosphorane intermediates produced in the reaction between triphenylphosphine, ammonium thiocyanate (or ammonium acetate) and various dialkyl acetylenedicarboxylates was developed.

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Sigma-Aldrich
Ammonium thiocyanate, ACS reagent, ≥97.5%
Sigma-Aldrich
Ammonium thiocyanate, powder
Supelco
Ammonium thiocyanate, 99.99% trace metals basis
Sigma-Aldrich
Ammonium thiocyanate, SAJ special grade, ≥99%
Sigma-Aldrich
Ammonium thiocyanate solution, 0.1 M, 1/10 N