- Structure and conformational dynamics of trichothecene mycotoxins.
Structure and conformational dynamics of trichothecene mycotoxins.
Journal of natural products (2008-03-11)
Wayne E Steinmetz, Paul Robustelli, Eric Edens, David Heineman
PMID18327910
RESUMEN
A combination of NMR spectroscopy and molecular modeling has been employed to characterize the conformation and dynamics of the macrolide ring in verrucarin A and roridin A, two closely related toxins in the trichothecene mycotoxin family. Longitudinal carbon-13 relaxation times demonstrate the relative flexibility of the macrolide ring. The calculations, NOEs, and scalar vicinal coupling constants show that verrucarin A in CDCl 3 and CD 2Cl 2 predominantly adopts a single, well-defined conformation that matches the crystal structure. In contrast, roridin A is present as a mixture of two conformers.
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Nivalenol in acetonitrile, IRMM®, certified reference material
4-Deoxynivalenol in acetonitrile, IRMM®, certified reference material