- N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.
N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.
Journal of medicinal chemistry (2009-12-18)
Zheng Yin, Yen-Liang Chen, Ravinder Reddy Kondreddi, Wai Ling Chan, Gang Wang, Ru Hui Ng, Joanne Y H Lim, Wan Yen Lee, Duraiswamy A Jeyaraj, Pornwaratt Niyomrattanakit, Daying Wen, Alex Chao, J Fraser Glickman, Hans Voshol, Dieter Mueller, Carsten Spanka, Sigmar Dressler, Shahul Nilar, Subhash G Vasudevan, Pei-Yong Shi, Thomas H Keller
PMID20014868
RESUMEN
A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.