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Key Documents

SRP3310

Sigma-Aldrich

IL-1ALPHA human

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Sinónimos:

Endogenous Pyrogen (EP), Hematopoietin-1, Lymphocyte-activating factor (LAF)

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

potency

≤0.001 ng/mL

mol wt

18.0 kDa

packaging

pkg of 10 μg

impurities

endotoxin, tested

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL1A(3552)

General description

IL-1α (interleukin) is one of the three isoforms of IL-1, the other two being IL-1β and IL-1Rα. It is a proinflammatory macrophage cytokine. IL-1α is produced de novo and can either be actively secreted or can be released passively by apoptotic cells. This gene is localized to human chromosome 2q13–2q14.1.
Recombinant human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.

Biochem/physiol Actions

IL-1α (interleukin) and IL-1β bind with IL-1 receptor and function as proinflammatory cytokines, whereas IL-1Rα competes to bind with IL-1R but is not proinflammatory. IL-1α can function as an intracrine molecule or as a transcription factor. IL-1 plays a major role in ischemic brain damage, as the inactivation of both IL-1α and IL-1β lead to significant suppression in brain injury. However, inactivation of only IL-1α does not have much influence on overall damage due to some compensatory modifications in the IL-1 system. A hospital-based case-control study showed that rs3783553 variant in this gene is linked with reduced risk of breast cancer. Tumor cell production of IL-1α helps their transmigration across the endothelium, and the expression of IL-1α is linked with distant metastasis in patients with head and neck squamous cell carcinoma.

Physical form

Lyophilized from 3.2 mM Tris, pH 8.3 + 16 mM NaCl.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Los clientes también vieron

Role of IL-1alpha and IL-1beta in ischemic brain damage.
Boutin H et al
The Journal of Neuroscience, 21(15), 5528-5534 (2001)
Macrophage cytokines: involvement in immunity and infectious diseases.
Arango Duque G and Descoteaux
Frontiers in Immunology, 5(491) (2014)
A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer.
Huang X et al
Genetics and molecular research : GMR, 15(1), gmr-gmr (2016)
Starnes, T. et al.
Journal of Immunology, 2, 642- 646 (2002)
Expression of IL-1a correlates with distant metastasis in patients with head and neck squamous cell carcinoma.
Leon X et al
Oncotarget, 6(35), 37398-37409 (2015)

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