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Key Documents

SAB4502158

Sigma-Aldrich

Anti-BRP44L antibody produced in rabbit

affinity isolated antibody

Sinónimos:

MPC1, Mitochondrial pyruvate carrier 1, Brain protein 44-like protein

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 12 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BR44L(51660)

General description

MPC1 (mitochondrial pyruvate carrier 1) gene is mapped to human chromosome 6q27. MPC1 encodes a 12kDa, protein containing five exons and two membrane spanning α helixes. Anti-BRP44L Antibody detects endogenous levels of total BRP44L protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human BRP44L.

Immunogen Range: 11-60

Application

Anti-BRP44L antibody produced in rabbit has been used to check the effect of mitochondrial TOM70 (translocase of the outer membrane protein 70) on MPC1 (mitochondrial pyruvate carrier 1) expression.

Biochem/physiol Actions

MPC1 (mitochondrial pyruvate carrier 1) is a key player in pyruvate metabolism. It transports pyruvate into the inner mitochondrial matrix. Lowered MPC1 expression, elevates glycolysis due to a shift in metabolism to fatty acid oxidation. This accounts for the pathogenesis of cancer and other diseases. Downregulation of this gene is observed in colon adenocarcinoma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)
Sandoval IT, et al.
eLife, 6(28), e22706-e22706 (2017)
TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer
Filadi R, et al.
Current Biology, 28(3), 369-382 (2018)
Defective expression of the mitochondrial-trna modifying enzyme GTPBP3 triggers AMPK-mediated adaptive responses involving complex I assembly factors, uncoupling protein 2, and the mitochondrial pyruvate carrier
Martinez-Zamora A, et al.
PLoS ONE, 10(12), e0144273-e0144273 (2015)
Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells
Li X, et al.
Testing, 8(28), 46363-46363 (2017)
Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses
Li X, et al.
Oncotarget, 7(48), 79981-79994 (2016)

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